Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation

L Swain, S Bhave, X Qiao, L Reyelt, K Everett, J Awata… - Circulation, 2024 - Am Heart Assoc
… -ECMO on myocardial damage in acute myocardial infarction remains … myocardial cardiolipin
and exacerbates myocardial injury in … Extracorporeal membrane oxygenation in myocardial

Transvalvular unloading mitigates ventricular injury due to venoarterial extracorporeal membrane oxygenation in acute myocardial infarction

KD Everett, L Swain, L Reyelt, M Majumdar… - Basic to Translational …, 2023 - jacc.org
… identify novel targets of therapy to reduce reperfusion injury … ECMO reduces mitochondrial
levels of cardiolipin, a critical … for myocardial oxygen consumption, myocardial damage due to

Transvalvular ventricular unloading before reperfusion in acute myocardial infarction

L Swain, L Reyelt, S Bhave, X Qiao, CJ Thomas… - Journal of the American …, 2020 - jacc.org
… not with venoarterial extracorporeal membrane oxygenation (… Reperfusion also reduce levels
of cardiolipin, an integral … FCCP treatment failed to increase the rate of oxygen consumption …

Innovating to resolve the pressure-oxygenation-paradox created by VA-ECMO could improve outcomes for acute myocardial infarction and cardiogenic shock

NK Kapur - The Journal of Heart and Lung Transplantation, 2024 - Elsevier
… Bartlett, veno-arterial extracorporeal membrane oxygenation (… Since LV load increases
myocardial oxygen consumption … which synthesizes the lipoprotein cardiolipin and is essential for …

[HTML][HTML] Mitofilin in Cardiovascular Diseases: Insights into the Pathogenesis and Potential Pharmacological Interventions

AI Chaurembo, N Xing, F Chanda, Y Li, H Zhang… - Pharmacological …, 2024 - Elsevier
therapeutic agents that target the mitochondria to prevent CVD. This would help reduce the
significant burden caused by … binds cardiolipin and regulates its levels, suggesting its role in …

871: SUCCESSFUL PATIENT MANAGEMENT OF MASSIVE HEMOPTYSIS ON VENO-ARTERIAL EXTRACORPOREAL MEMBRANE OXYGENATOR (VA ECMO)

M Harrison, S Cowan, H Hirose, L Bogar… - Critical Care …, 2011 - journals.lww.com
… ligands reduce myocardial ischemia-reperfusion (I/R) injury. … Mitochondrial reactive oxygen
species have become a target for drug … c with cardiolipin leading to mitochondrial membrane

[HTML][HTML] Mitochondrial metabolism in myocardial remodeling and mechanical unloading: implications for ischemic heart disease

M Jiang, X Xie, F Cao, Y Wang - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
… In conclusion, by reestablishing the oxygen supply-… , particularly venoarterial extracorporeal
membrane oxygenation (… structure, including cardiolipin content induced by IR injury. Further …

Coronavirus disease‐19 and cardiovascular disease: A risk factor or a risk marker?

J Liu, SS Virani, M Alam, AE Denktas… - Reviews in Medical …, 2021 - Wiley Online Library
… to oxygen supply-demand mismatch and acute myocardial … Case reports have found positive
anti-cardiolipin IgA and anti–… venous-arterial extracorporeal membrane oxygenation (ECMO…

[HTML][HTML] Veno-venous extracorporeal membrane oxygenation in minipigs as a robust tool to model acute kidney injury: technical notes and characteristics

A Szabó-Biczók, G Varga, Z Varga, G Bari… - Frontiers in …, 2022 - frontiersin.org
novel targets and to improve clinical outcomes of vv-ECMO-… triggering factors or targeted
specific therapies to prevent the … key components of the local, tissue oxygen delivery (DO 2 ). …

COVID-19—Toward a comprehensive understanding of the disease

MM Kowalik, P Trzonkowski… - Cardiology …, 2020 - journals.viamedica.pl
… Interestingly, there have been reports of transient anticardiolipin IgA, anti-B2-glycoprotein …
intensive therapy treatment (oxygen therapy, methods of ventilation, extracorporeal membrane